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Regarding the film, Every Secret Thing, Katherine Pushkar from the New York Daily News wrote, "The film actually belongs to Danielle Macdonald, effective as cruel, jealous Alice."
Macdonald was originally booked for the role of Becca on ABC's show Huge. Unfortunately, her Visa did not come in on time and she was unable to fulfill the role. Her first feature film was The East, premiered at the 2013 Sundance Film Festival. She also had a supporting role in the film Trust Me.
In 2016, she appears in the season finale of American Horror Story: Roanoke as Bristol Windows.